NMD-VCell Research Workbench Module: Validate / registry · evidence-to-experiment workflow NMD = neuromuscular disorders
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary

Benchmark center

Four benchmark questions, four independent routes.

The same-context audit, external aggregate transfer, G0–G7 generalization contract and VCC 2026 readiness audit are separated so their denominators and claim boundaries cannot drift into one another.

01 · Same-context

Core HepG2 benchmark

Repeated-fold error, raw direction, residual structure and the 16 frozen strict outcomes.

Open core benchmark →
02 · External aggregate

External-transfer diagnostic

Formula-aligned aggregate metrics on 55 Frangieh targets; no directional-transfer support.

Open external transfer →
03 · OOD matrix

G0–G7 generalization ladder

Unseen perturbation, family, donor, state, laboratory, disease and modality are reported independently.

Open generalization ladder →
04 · Future-task audit

VCC 2026 readiness

Infrastructure gap matrix, official-source watch and task-binding locks before launch.

Open VCC readiness →
Boundary. Results on one route do not upgrade another. The external 55-target object is not a VCC score, and VCC readiness is not task compatibility.