NMD-VCell Research Workbench Module: Validate / registry · evidence-to-experiment workflow NMD = neuromuscular disorders
Search Release v1.0 candidate
Governance ▾
Scientific program Methods Claim boundary Benchmarks v1 release gate v1 authorization Prediction gate Registry Transitions Maintenance
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary

External-transfer diagnostic

55-target aggregate transfer remains unsupported

The metric adapter executes on an external aggregate-delta object. It is useful for method diagnostics but is neither cell-distribution evaluation nor a VCC submission score.

← Benchmark center

Executed now · bounded diagnostic

Multi-metric run on 55 external aggregate perturbation targets

MAE-delta, delta correlation and L1-PDS now run beside the same ridge, training-mean and zero-change predictions. The source endpoint remains NO_DIRECTIONAL_TRANSFER_SUPPORT.

AGGREGATE · NOT VCC
Target-bootstrap point estimates; lower is better for RMSE/MAE, higher is better otherwise.
MethodRMSE ΔMAE ΔPDS L1Pearson ΔSpearman ΔEffect-size ρ
Safe ridge transferdiagnostic model 1.0928 0.1861 0.5147 -0.0148 -0.0013 -0.0554
Training-response meanbaseline 1.0925 0.1844 0.5134 -0.0161 -0.0027 undefined
Zero changebaseline 1.0896 0.1707 0.5134 undefined undefined undefined
PDS scale auditRaw prediction multiplier
0.00× 0.5134
0.25× 0.5154
0.50× 0.5164
1.00× 0.5147
2.00× 0.5144
4.00× 0.5134
8.00× 0.5193

Truth-norm matched: 0.5431 · median factor 14.52×. This uses paired observed norms and is sensitivity-only, never a fair hidden-test score.

What changed. The metric engine is operational on aggregate deltas. DES/DEG recovery and cell-distribution metrics remain locked because this prediction object has no genuine cell-level distribution.

Open executed JSON Download 55-target table Read execution report Download metric runner
Execution boundary. This is a formula-aligned aggregate-delta diagnostic, not an official cell-eval run, not a VCC 2025 rescore, and not a VCC 2026 task execution. No muscle, DMD, treatment or clinical validity follows from these scores.