NMD-VCell Research Workbench Module: Validate / registry · evidence-to-experiment workflow NMD = neuromuscular disorders
Search Release v1.0 candidate
Governance ▾
Scientific program Methods Claim boundary Benchmarks v1 release gate v1 authorization Prediction gate Registry Transitions Maintenance
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary

Scientific program · released contract

From candidate triage to testable DMD state transitions.

The core object is now perturbation × cell state × disease context × time × phenotype. A gene alone is not the unit of biological validation.

Open the 24-slot pilotOpen generalization ladderProgram JSON

Two tracks · separate gates

General virtual-cell performance and DMD validity cannot substitute for one another

Competition Generalist Track

Transport across contexts

Unseen perturbation, donor, state, dataset and calibrated abstention. Primary outputs are pseudobulk response and, when cell-level truth exists, a predicted cell population.

Inspect G0–G7

DMD Scientific Track

Replicate disease-relevant function

DMD and matched control, functional primary endpoint, target engagement, toxicity, reagent concordance, donor heterogeneity and prospective outcome registration.

Inspect pilot contract

Mechanism chain

Every priority perturbation must connect early mechanism to late function

Perturbationdirection, modality, dose and engagement
6–12 hearly molecular response
24–48 hregulatory program and state transition
4–7 dfunction, toxicity and cross-cell consequence

These windows are planning defaults and must be calibrated to the selected cell system before registration.

Flagship studies

Three research programs, all truthfully locked at their current state

DMD-MIN-PERTURBOME

DMD Minimum Perturbome

Which perturbations produce reproducible DMD-relevant functional effects?

DRAFT_PROTOCOL_NO_EXPERIMENT_STARTED
DMD-STATE-ATLAS

DMD State-Specific Perturbation Atlas

How do perturbation effects change across myogenic state, time and microenvironment?

REGISTERED_DATA_MODEL_DATA_MISSING
NMD-PROSPECTIVE-CHALLENGE

Prospective NMD-VCell Challenge

Does frozen model selection improve future experimental hit rate over random, expert and simple baselines?

REGISTERED_FRAMEWORK_NO_PREDICTIONS_OR_OUTCOMES

Governed evidence transition

The next release is earned by outcomes, not by adding pages

STUDY CARD21editable drafts
REGISTERED STUDY0immutable protocol
EXPERIMENT0in flight
OUTCOME0success, null, toxic or inconclusive
TRANSITION0governed evidence change
Current boundary. v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release. This program object adds a preregistration and evaluation contract; it does not add experimental evidence.