{
  "program_schema": "nmd-vcell-scientific-program/1.0",
  "object_id": "PROGRAM:v1.0.0-database-resource:STATE-TRANSITION:1.0",
  "resource_release": "v1.0.0-database-resource",
  "evidence_freeze": "2026-07-25",
  "interface_build": "EA-20260729-15",
  "lifecycle": {
    "state": "RELEASED_PROGRAM_CONTRACT",
    "result_records": 0,
    "registered_studies": 0,
    "measured_outcomes": 0
  },
  "scientific_object": "perturbation × cell state × disease context × time × phenotype",
  "primary_question": "Which perturbation changes a DMD-relevant cell-state transition and function without unacceptable toxicity, and does that effect replicate across reagent, donor and batch?",
  "tracks": [
    {
      "track_id": "competition_generalist",
      "purpose": "Cross-context, cross-perturbation and population-level virtual-cell prediction.",
      "primary_gates": [
        "unseen perturbation",
        "unseen donor",
        "unseen state",
        "unseen dataset or laboratory",
        "calibrated abstention"
      ],
      "claim_boundary": "Competition scores do not establish DMD biological validity."
    },
    {
      "track_id": "dmd_scientific",
      "purpose": "Disease-relevant function, donor and reagent replication, mechanism and prospective experimental hit rate.",
      "primary_gates": [
        "DMD and matched-control context",
        "functional primary endpoint",
        "two-reagent concordance",
        "multi-donor replication",
        "prospective outcome registration"
      ],
      "claim_boundary": "A small DMD study does not establish general virtual-cell transportability."
    }
  ],
  "flagship_programs": [
    {
      "program_id": "DMD-MIN-PERTURBOME",
      "title": "DMD Minimum Perturbome",
      "question": "Which perturbations produce reproducible DMD-relevant functional effects?",
      "current_state": "DRAFT_PROTOCOL_NO_EXPERIMENT_STARTED"
    },
    {
      "program_id": "DMD-STATE-ATLAS",
      "title": "DMD State-Specific Perturbation Atlas",
      "question": "How do perturbation effects change across myogenic state, time and microenvironment?",
      "current_state": "REGISTERED_DATA_MODEL_DATA_MISSING"
    },
    {
      "program_id": "NMD-PROSPECTIVE-CHALLENGE",
      "title": "Prospective NMD-VCell Challenge",
      "question": "Does frozen model selection improve future experimental hit rate over random, expert and simple baselines?",
      "current_state": "REGISTERED_FRAMEWORK_NO_PREDICTIONS_OR_OUTCOMES"
    }
  ],
  "evidence_transition": "Study Card → Registered Study → Experiment → Outcome → Governed evidence transition",
  "claim_boundary": "v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release."
}