NMD-VCell Research Workbench Module: Study design · evidence-to-experiment workflow NMD = neuromuscular disorders
Search Release v1.0 candidate
Governance ▾
Scientific program Methods Claim boundary Benchmarks v1 release gate v1 authorization Prediction gate Registry Transitions Maintenance
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary

Plan an experiment

Study design

Design the next experiment before browsing the card ledger.

Search a gene, generate a bounded scaffold, or open one of three recommended examples. The planner does not rank candidates or upgrade evidence levels.

ZNF133 CPEB1 GFOD2

No gene selected.

Recommended examples: ZNF133 · CPEB1 · GFOD2.

Planner visual builder

Turn one gene into a bounded experiment route.

The planner is a CONSORT-style research workflow: it resolves a gene, shows the frozen evidence state, exposes the blocking gap, selects the current assay route and lists the registration fields still open.

BoundaryThis builder does not rank candidates, change evidence levels, compute target scores, infer therapeutic direction or make disease-prediction claims.
Draft Study Cards21stable governed routes
Action classes5current next-step categories
L3b replications0same-perturbation evidence absent
Prediction statusP0P1/P2 remain locked
1Resolve geneHGNC identifier and typed record
2Evidence stateL1/L2/L3a fields only
3Blocking gapgap code stays explicit
4Assay routeaction-specific scaffold
5Register draftrequires frozen fields

Current Study Card action map

Muscle-context assay2 Study Cards
Independent human myogenic perturbation test; highest-value wet-lab escalation.
Verify expression4 Study Cards
Confirm target detectability before perturbation escalation.
Risk/context review7 Study Cards
Resolve dependency, toxicity or context risks before wet-lab escalation.
Computational replication7 Study Cards
Replicate source-state evidence in an independent frozen analysis.
Evidence import audit1 Study Card
Import and audit author-reported external evidence before changing state.

Stable governed records

Versioned Study Cards grouped by current action

All 21 routes are static, shareable and tied to v1.0.0-database-resource, schema 1.1 and build EA-20260729-15. JSON, YAML and TSV exports are available on every card.

Muscle-context assay

2 Study Cards

Independent human myogenic perturbation test; highest-value wet-lab escalation.

2
MON1A · Muscle-context assayZNF133 · Muscle-context assay

Verify expression

4 Study Cards

Confirm target detectability before perturbation escalation.

4
CPEB1 · Verify expressionDNAAF3 · Verify expressionEPS8L1 · Verify expressionZFP69B · Verify expression

Risk/context review

7 Study Cards

Resolve dependency, toxicity or context risks before wet-lab escalation.

7
INTS13 · Risk/context reviewNAGLU · Risk/context reviewRAC3 · Risk/context reviewRNASEH2C · Risk/context reviewRNF8 · Risk/context reviewWDR4 · Risk/context reviewZNF236 · Risk/context review

Computational replication

7 Study Cards

Replicate source-state evidence in an independent frozen analysis.

7
ADAM10 · Computational replicationCALR · Computational replicationDDX19B · Computational replicationDNM1 · Computational replicationEHMT2 · Computational replicationLMO2 · Computational replicationMPHOSPH6 · Computational replication

Evidence import audit

1 Study Card

Import and audit author-reported external evidence before changing state.

1
GFOD2 · Provisional hold · external report not yet audited