NMD-VCell Research Workbench Module: Study design · evidence-to-experiment workflow NMD = neuromuscular disorders
Search Release v1.0 candidate
Governance ▾
Scientific program Methods Claim boundary Benchmarks v1 release gate v1 authorization Prediction gate Registry Transitions Maintenance
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary
Historical audit routeThese fields do not define the current research decision. Return to current hypotheses.

Historical audit layer

Legacy v0.6 ranking fields retained for reproducibility

These fields are not the current decision interface. Current authority is action then gene, with no current numeric rank.

Historical fields and source-state details for all 21 governed hypotheses
GeneEvidence classCurrent action Observed DMD-prior counteralignmentPredictive support DMD-source agreementHistorical rank interval Skeletal-muscle expressionMyoblast screen state Dependency cautionMissing evidence
CPEB1 Conflicted Verify expression 0.0118 strict direct gate not supported 67% 6–12 0.731 TPM · below 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; source-consistent DMD direction; muscle-expression confirmation
DNAAF3 Conflicted Verify expression 0.0344 strict direct gate not supported 100% 6–10 0.076 TPM · below 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; muscle-expression confirmation
EPS8L1 Conflicted Verify expression 0.0036 strict direct gate not supported 100% 11–17 0.236 TPM · below 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; muscle-expression confirmation
Low skeletal-muscle expression warning: ZFP69B Conflicted Verify expression 0.0563 strict direct gate not supported 67% 3–3 0.155 TPM · below 1 TPMIndependent muscle-expression confirmation required. Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; source-consistent DMD direction; muscle-expression confirmation
INTS13 Conflicted Risk/context review 0.0193 strict direct gate not supported 100% 18–20 10.991 TPM · above 1 TPM Not assessed Moderate-dependency caution muscle perturbation; myoblast fusion screen
NAGLU Conflicted Risk/context review 0.011 strict direct gate not supported 75% 19–19 8.664 TPM · above 1 TPM Assessed · no current hit Moderate-dependency caution muscle perturbation; source-consistent DMD direction
RAC3 Conflicted Risk/context review 0.0248 strict direct gate not supported 75% 15–20 0.339 TPM · below 1 TPM Not assessed Moderate-dependency caution muscle perturbation; myoblast fusion screen; source-consistent DMD direction; muscle-expression confirmation
RNASEH2C Conflicted Risk/context review 0.0217 strict direct gate not supported 100% 15–16 9.526 TPM · above 1 TPM Assessed · no current hit Moderate-dependency caution muscle perturbation
RNF8 Conflicted Risk/context review 0.0394 strict direct gate not supported 50% 17–18 4.105 TPM · above 1 TPM Not assessed Moderate-dependency caution muscle perturbation; myoblast fusion screen; source-consistent DMD direction
WDR4 Conflicted Risk/context review 0.0185 strict direct gate not supported 100% 21–21 4.159 TPM · above 1 TPM Assessed · no current hit Moderate-dependency caution muscle perturbation
ZNF236 Conflicted Risk/context review 0.0596 strict direct gate not supported 50% 4–4 2.007 TPM · above 1 TPM Not assessed Moderate-dependency caution muscle perturbation; myoblast fusion screen; source-consistent DMD direction
MON1A Conflicted Muscle-context assay 0.0465 strict direct gate not supported 50% 5–5 8.057 TPM · above 1 TPM Assessed · no current hit No moderate-dependency flag muscle perturbation; source-consistent DMD direction
ZNF133 Conflicted Muscle-context assay 0.0638 strict direct gate not supported 75% 2–2 4.558 TPM · above 1 TPM Assessed · no current hit No moderate-dependency flag muscle perturbation; source-consistent DMD direction
ADAM10 Conflicted Computational replication 0.0166 strict direct gate not supported 50% 8–9 3.116 TPM · above 1 TPM Assessed · no current hit No moderate-dependency flag muscle perturbation; source-consistent DMD direction
CALR Conflicted Computational replication 0.0343 strict direct gate not supported 75% 7–7 88.631 TPM · above 1 TPM Assessed · no current hit No moderate-dependency flag muscle perturbation; source-consistent DMD direction
DDX19B Conflicted Computational replication 0.0181 strict direct gate not supported 50% 9–10 7.229 TPM · above 1 TPM Assessed · no current hit No moderate-dependency flag muscle perturbation; source-consistent DMD direction
DNM1 Conflicted Computational replication 0.0024 strict direct gate not supported 50% 14–16 1.4 TPM · above 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; source-consistent DMD direction
EHMT2 Conflicted Computational replication 0.0298 strict direct gate not supported 75% 8–11 6.406 TPM · above 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; source-consistent DMD direction
LMO2 Conflicted Computational replication 0.0072 strict direct gate not supported 75% 12–14 15.237 TPM · above 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; source-consistent DMD direction
MPHOSPH6 Conflicted Computational replication 0.0156 strict direct gate not supported 100% 13–13 4.946 TPM · above 1 TPM Assessed · no current hit No moderate-dependency flag muscle perturbation
GFOD2 Conflicted Provisional hold · external report not yet audited 0.0741 strict direct gate not supported 50% 1–1 2.947 TPM · above 1 TPM Not assessed No moderate-dependency flag muscle perturbation; myoblast fusion screen; source-consistent DMD direction
Legacy schema and field-name note

The downloadable candidate_evidence_vector_v06.tsv and historical status rows retain prior A/B/C fields, scores and ranks. They do not define a current winner.