{
  "registry_schema": "nmd-vcell-prediction-registry/1.0",
  "resource_release": "v1.0.0-database-resource",
  "interface_build": "EA-20260729-15",
  "registry_status": "empty_scaffold_no_predictions_registered",
  "claim_state": "P0_prediction_infrastructure_ready_P1_unvalidated_P2_locked",
  "counts": {
    "prediction_registered": 0,
    "outcome_measured": 0,
    "abstained_predictions": 0,
    "failed_predictions": 0,
    "passed_predictions": 0
  },
  "schemas": {
    "prediction_card": "downloads/prediction_card.schema.json",
    "outcome_board": "downloads/outcome_board.schema.json",
    "external_validation_import_template": "downloads/external_validation_import_template.json"
  },
  "records": [],
  "outcomes": [],
  "empty_registry_semantics": "No prediction has been prospectively registered and no outcome has been measured in this release. The empty registry is an integrity state, not evidence of model failure or success.",
  "p1_unlock_requires": [
    "frozen DMD/dystrophin-deficient human myogenic or neuromuscular perturbation dataset",
    "train/validation/external-test partition declared before model fitting",
    "donor, isogenic-pair or perturbation unit of analysis declared",
    "negative, positive and rescue/control definitions predeclared",
    "primary functional endpoint and transcriptomic secondary endpoints frozen",
    "baseline models, calibration, uncertainty intervals and abstention policy benchmarked",
    "out-of-distribution detection and failure-mode taxonomy frozen",
    "prospective prediction cards timestamped before outcome access",
    "outcome board populated without relabelling failed or abstained predictions"
  ],
  "p2_unlock_requires": [
    "clinical intended-use statement",
    "independent external clinical validation",
    "decision-impact or workflow evaluation protocol",
    "bias, safety, monitoring and human-oversight plan",
    "regulatory and ethics review appropriate to intended use"
  ],
  "not_authorized_claims": [
    "validated DMD disease predictor",
    "therapeutic response predictor",
    "clinical decision-support platform",
    "treatment-prioritization engine"
  ]
}