{
  "schema_version": "1.1",
  "resource_release": "v1.0.0-database-resource",
  "evidence_freeze": "2026-07-25",
  "gene": "ZNF133",
  "identifiers": {
    "aliases": [
      "pHZ-13",
      "pHZ-66"
    ],
    "approved_symbol": "ZNF133",
    "ensembl_gene_id": "ENSG00000125846",
    "hgnc_id": "HGNC:12917",
    "ncbi_gene_id": 7692,
    "previous_symbols": [
      "ZNF150"
    ],
    "species": "Homo sapiens",
    "symbol_status": "approved"
  },
  "highest_supported_level": "L2_observed_same_context_perturbation",
  "highest_assessed_level": "L3a_external_context_screen",
  "evidence_status": {
    "resource_record": {
      "assessment_status": "assessed",
      "support_status": "supported"
    },
    "observed_hepg2_perturbation": {
      "assessment_status": "assessed",
      "support_status": "supported",
      "observed_cells": 84
    },
    "internal_model_support": {
      "assessment_status": "assessed",
      "support_status": "supported_with_limits",
      "target_specific_predictive_support": "not_supported",
      "ood_status": "not_assessed",
      "context": "same_processed_hepg2_dataset"
    },
    "external_context_screen": {
      "assessment_status": "assessed",
      "support_status": "context_evidence_present",
      "hit": false,
      "effect_size": -0.003533,
      "fdr": 0.999999,
      "context": "GSE293514_myoblast_fusion_screen",
      "interpretation": "assessed_no_current_hit"
    },
    "independent_perturbation_replication": {
      "assessment_status": "not_assessed"
    },
    "dmd_muscle_validation": {
      "assessment_status": "not_assessed"
    },
    "functional_validation": {
      "assessment_status": "not_assessed"
    },
    "therapeutic_utility": {
      "assessment_status": "not_assessed"
    }
  },
  "decision": {
    "current_action": "muscle_assay",
    "current_display_label": "Muscle-context assay",
    "current_numeric_rank": null,
    "formal_deprioritization": false,
    "historical_rank": 2,
    "historical_rank_is_current": false
  },
  "evidence_gaps": {
    "decision_blocking_gap": {
      "code": "GAP-02",
      "label": "Independent muscle-context perturbation is absent"
    },
    "highest_missing_evidence_layer": "L4_dmd_functional_validation",
    "secondary_gaps": [
      "GAP-03 DMD-relevant functional validation",
      "GAP-07 independent replication"
    ]
  },
  "dmd_context": {
    "integrated_prior_direction": "up",
    "source_direction_state": "conflicted",
    "source_direction_agreement": {
      "agreeing_sources": 3,
      "assessed_sources": 4,
      "directional_sources": 4,
      "proportion": 0.75
    },
    "variant_stability_state": "sign_varied_across_variants",
    "variant_count": 9,
    "evidence_module_memberships": [
      "direction_conflicted"
    ],
    "statistical_support_state": "direction_only_no_significant_context_rows",
    "coverage_state": "4_of_4_sources",
    "integration_method": "median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately",
    "uncertainty_state": "direction_conflict_retained",
    "conflict_reason": "3 source(s) positive and 1 source(s) negative",
    "integrated_direction_is_prior_not_ground_truth": true,
    "consensus_direction": "up_in_dmd",
    "consensus_direction_deprecation": {
      "deprecated": true,
      "replacement": "integrated_prior_direction",
      "policy": "retained for one schema cycle; do not interpret as study consensus"
    }
  },
  "context_metrics": {
    "skeletal_muscle_median_tpm": 4.55781,
    "depmap_median_gene_effect": -0.0375505223925062,
    "moderate_dependency_flag": false,
    "observed_counteralignment": 0.0638177433316608
  },
  "summary": "Current next action: Muscle-context assay. No current numeric rank; historical fields remain available for reproducibility.",
  "links": {
    "research_record": "gene/ZNF133",
    "detailed_audit_record": "gene/ZNF133/audit",
    "legacy_api_record": "api/v1/genes/ZNF133.json",
    "release_manifest": "api/v1.1/release_manifest.json"
  }
}