{
  "catalog_schema": "nmd-vcell-dataset-catalog/1.0",
  "interface_build": "EA-20260729-20",
  "resource_release": "v1.0.0-database-resource",
  "evidence_freeze": "2026-07-25",
  "dataset_count": 5,
  "records": [
    {
      "dataset_id": "NMDVCELL-HEPG2-CRISPRI",
      "accession": "internal-release-substrate",
      "title": "Observed HepG2 CRISPRi candidate responses",
      "disease": "Context-limited; not DMD",
      "cell_type": "HepG2",
      "perturbation": "CRISPRi single-gene",
      "timepoints": "Frozen endpoint aggregate",
      "endpoints": "2,000-dimensional response vector",
      "sample_size": "21 governed candidate aggregates",
      "candidate_coverage": "21/21",
      "permitted_role": "Direct same-context perturbation observation",
      "raw_data": "Component-resolved release objects",
      "license": "Internal release licence pending institutional approval",
      "url": "/resource/candidates"
    },
    {
      "dataset_id": "GSE293514",
      "accession": "GSE293514",
      "title": "Human myoblast fusion CRISPR screen",
      "disease": "Muscle context; not DMD rescue",
      "cell_type": "Human myoblast",
      "perturbation": "Knockout screen",
      "timepoints": "Publication endpoint",
      "endpoints": "Fusion screen and individual validation subset",
      "sample_size": "9/21 candidates represented in library",
      "candidate_coverage": "9/21; 0 current fusion hits",
      "permitted_role": "External muscle-context screen (L3a), not replication",
      "raw_data": "Source workbooks checksummed",
      "license": "Source repository and publication terms apply; verify at accession",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293514"
    },
    {
      "dataset_id": "GSE272233",
      "accession": "GSE272233",
      "title": "DMD-locus CRISPR-correction transcript reference",
      "disease": "Duchenne muscular dystrophy",
      "cell_type": "Patient-derived and corrected cellular models",
      "perturbation": "DMD-locus correction",
      "timepoints": "Study endpoint",
      "endpoints": "Bulk RNA expression and correction contrasts",
      "sample_size": "21 samples; 3 per reported group",
      "candidate_coverage": "Candidate transcripts observed; no candidate perturbation",
      "permitted_role": "Orthogonal disease-correction reference",
      "raw_data": "Processed matrix checksummed",
      "license": "Source repository and publication terms apply; verify at accession",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272233"
    },
    {
      "dataset_id": "GSE52529",
      "accession": "GSE52529",
      "title": "Human myogenic differentiation time course",
      "disease": "Non-disease trajectory reference",
      "cell_type": "Primary human skeletal myoblast",
      "perturbation": "None",
      "timepoints": "0, 24, 48 and 72 hours",
      "endpoints": "Single-cell expression, state and pseudotime",
      "sample_size": "271 cells",
      "candidate_coverage": "20/21 measured",
      "permitted_role": "Unperturbed trajectory reference only",
      "raw_data": "Bioconductor source package checksummed",
      "license": "Source repository and package terms apply; verify at accession",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE52529"
    },
    {
      "dataset_id": "GSE133344",
      "accession": "GSE133344",
      "title": "CRISPRa single and combinatorial calibration reference",
      "disease": "Non-muscle method calibration",
      "cell_type": "K562",
      "perturbation": "CRISPRa singles and pairs",
      "timepoints": "Study endpoint",
      "endpoints": "Single-cell gene expression",
      "sample_size": "287 perturbations; 112 singles; 132 pairs",
      "candidate_coverage": "20/21 present as expression features",
      "permitted_role": "Method calibration only; not muscle/DMD overexpression evidence",
      "raw_data": "Processed feature table checksummed",
      "license": "Source repository and publication terms apply; verify at accession",
      "url": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133344"
    }
  ],
  "boundary": "Catalog inclusion does not upgrade a dataset to direct DMD candidate-perturbation replication."
}